In what way do serotonin modulators differ from reuptake inhibitors?


Active member
I've never heard the term serotonin modulator before. But according to Wikipedia, serotonin modulators are reuptake-inhibitors that also bind to serotonin-receptors (agonistic or antagonistic).

Especially for antidepressants of the SRI type which are also inhibiting some serotonin-receptor subtypes.
I am not surprised that I don't know the term, I also haven't heard of those drugs yet. Vilazodone, Vortioxetine.


Well-known member
What @Zebra said is right, but the term*serotonin modulator alone doesn't imply reuptake inhibition, so the term serotonin modulator and stimulator is used.

Serotonin modulator can mean lots of things.


Active member
But I’d argue this could be achieved better with 5-ht2a. And mianserin has lower affinity to H1 relative to mirtazapine.