How do NRIs work?

Anderson

Well-known member
How do NRIs work? They increase the extracellular concentration of noradrenaline and increase adrenergic activity but how do they do that? And why does that helps with depression? (doesn't that involve other neurotransmitters as well?)
 

Green

Member
Ok so you know what a synapse is?

Where the electrical impulse is transformed into a chemical impulse and back into electrical.
 

Green

Member
Yes. Okay, so the action potential changes the depolarization. The ion that does usually go into the cell along the nerve is sodium.
 

Green

Member
Yes, but at the end of the neuron and the synapse, we call that the presynapse. There is calcium streaming inside the cell.
 

Green

Member
So at the presynapse you have voltage gated Ca2+ channels instead of voltage gated Na+channels, the Ca2+ triggers the release of the neurotransmitters and what's important to know is, 99% of the neurotransmitter is recycled back into the presynapse and put into vesicles again.
 

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Anderson

Well-known member
So NRIs inhibit the reuptake of noradrenalin and the noradrenalin remains into the post synaptic neuron?
 
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