How can tramadol and other opioids cause serotonin syndrome?

Jackie

Well-known member
Tramadol is a special case because it also inhibits the SERT (inhibits the re-uptake of serotonin back into the presynaptic neuron).
How other opioids can cause it, idk. I don't think about serotonin syndrome when a patient gets an SSRI and an opioid, unless it's tramadol.
 

Riley09

Active member
Tramadol is a special case because it also inhibits the SERT (inhibits the re-uptake of serotonin back into the presynaptic neuron).
How other opioids can cause it, idk. I don't think about serotonin syndrome when a patient gets an SSRI and an opioid, unless it's tramadol.
Okay, thanks.
 
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