I learned that the active ingredient in Hoodia is the appetite-suppressing molecule, P57, or oxypregnane steroidal glycoside P57AS3. In scarce clinical studies, P57 has been researched to evaluate its potential as an anti-obesity drug. It is theorized that P57 acts on the brain in a manner similar to glucose.
So there is no need for a modern man living somewhere in the US to take hoodia...Although hoodia is marketed as a suppressant to assist weight loss, there is no solid evidence that hoodia is effective. Interest in its use for appetite control and weight loss arose due to reports that native Africans use hoodia to scale back hunger during long hunts.